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Sanofi-Aventis, A French pharmaceutical company, informed regulatory obstacles for the approval of potential blockbuster drug Acomplia and not set any time duration to launch anti-obesity drug Acomplia in United states because of waiting approval from FDA (Food and Drug Administration) for sales in US.

Researchers found evidence that suggests Crohn's disease is caused by a weak immune response.
The study, published in The Lancet, also suggest that Sildenafil ( Viagra ) might help in the treatment of the disease.


Crohn's disease is a chronic inflammatory disorder that causes ulcerations in the small and large intestines. Many researchers consider Crohn's to be an autoimmune disease -- an illness that occurs when the body tissues are attacked by its own immune system. However, Anthony Segal, at University College London, UK, and colleagues found that the inflammation in Crohn's arises due to a weak immune response.


The investigators looked at the quantities of neutrophils that patients with Crohn's disease produce in response to trauma at sites in the bowel and on the skin surface. They found that in response to trauma, Crohn's disease patients produced much lower quantities of neutrophils and inflammatory mediators when compared with healthy individuals. Cultured blood cells were also abnormal in the patients. To test the inflammatory response to bacteria, the team also measured local inflammatory and blood flow changes in participants after injecting a harmless form of Escherichia Coli under their skin. In the healthy controls, blood flow in the area of inflammation increased approximately ten-fold by 24 hours. Crohn's disease patients, however, had much lower blood flow than controls. The researchers found that the abnormally low blood flow in Crohn's patients could be corrected by treatment with Sildenafil, indicating a possible role for the drug in the treatment of the disease.


The authors believe that in Crohn's disease, reduced or delayed recruitment of neutrophils to sites at which bacteria penetrate the intestinal wall might lead to the persistence of bacteria and other organic debris in the tissue. The body may respond to this build up of bacteria by secreting inflammatory molecules, which accumulate and lead to the development of chronic inflammation typical of Crohn's.


Source:http://www.xagena.it

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The sexual performance-enhancing pills produced by Pfizer Italia are once again doing very well: since the launch of Viagra, which happened on 14 October 1998, 44 million 680 thousand have bee sold in the country, 5 million of which only in the first six months of 2006, a rise of more than 10 pct compared with the same period of 2005. There was record consumption in Catania and Palermo, though Sicily is at the bottom of the list for consumption compared with other Italian regions.


IMS Health, a company specialized in marketing information for the pharmaceutical industry, has produced a Viagra ranking for cities, with particular emphasis on the drug's consumption in Sicily. From 1998 to 2005 in Catania, 2,087 blue pills were taken per a thousand men, and a total of 477,371 over a 7-year period. On average, 2.09 per Ctania inhabitant over 40. These are figures which put Catania in first place among Siciliancities for the consumption of Viagra, followed by Palermo, where 2,075 pills were taken per thousand men, for over half a million pills in 7 years. In the top ten cities for chemically-enhanced sex in Italy, first place goes to Rome (4,790), then Pistoia (4,755), Rimini (4,627), Florence (4,517), and Pisa (4,319).Milan is in fifteenth place (3,722), Naples in thirty-first (3,400), and Palermo in seventieth.


The last in the rankings for the drug against impotence is Potenza. In addition to Rome, statistics show record consumption in Tuscany (at the top of the regional rankings), Lazio and Emilia Romagna. Southern men don't use the pill much, and Sicily in eighteenth place, almost as if it were a matter of honour. The market for the drug against impotence is in expansion. In the first six months of 2006 turnover grew by 20 pct, an increase which is added to the one in 2005: 15 pct more than in 2004.



Source:http://www.agi.it

As many as 50 per cent of Chinese men aged between 40 and 70 are suffering from erectile dysfunction (ED), according to research released this week.
Furthermore, about 10 per cent of the national adult male population suffer some degree of ED.


However, only 10 per cent of ED suffers on the Chinese mainland take medical treatment, according to research sponsored by German pharmaceutical giant Bayer released in Guangzhou, capital of Guangdong Province, on Tuesday.


The study was based on a survey of at least 2,000 men aged between 20 and 75 in major cities such as Guangzhou and Beijing.


Compared with many foreign men, Chinese men remain extremely reluctant to talk about their sexual problems, although the majority of them think it is very important to satisfy the needs of their partners.


Going to see a doctor is torturous for Chinese ED sufferers, according to the survey.


Thirty-seven per cent of the respondents said they were too shy to talk about it to doctors; 16 per cent don't know which doctor to talk to; 12 per cent don't believe in treatment, while 30 per cent simply choose to wait for ED to disappear.


The results reflect a growing concern in the country that many men are unhappy due to their unsatisfactory sexual performance.



Source:http://www.chinadaily.com.cn



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